Auricula play translation5/30/2023 These studies were conducted by targeting relevant potential wound repair mechanisms such as the activation of epithelial cells- or fibroblasts proliferation and migration, the inhibition of reactive oxygen species (ROS) production, and the modulation of inflammatory mediators. In recent years, several researchers have investigated various kinds of natural products with regard to their wound-healing properties. Therefore, an attempt to identify any remedies that could effectively accelerate skin wound healing would be of significant interest. These factors include infection, necrotic tissue, vascular supply, co-existing physical factors (nutritional status), and disease states (diabetes, cancer, and arthritis). Despite the fact that the regular wound-healing process can simultaneously occur, many of intrinsic and extrinsic factors can interfere with the wound-healing process that can then result in an ultimate delay of wound repair. These steps contribute to the restoration of skin functions and mechanistically required the proliferation, migration, and differentiation of keratinocytes at the margins of the wound. Not only fibroblasts that are essential for the wound-healing process, but keratinocytes are indeed involved in critical steps, such as the epidermal regeneration and the closure of the wound. Fibroblast cells play an important role in facilitating the proliferative stage via the production of various enzymes that degrade the fibrin clot, then replace it with extracellular matrix (ECM) components (such as collagen and hyaluronic acid) and infiltrate the margins of the wound. Acute and chronic wounds involve a variety of interactions with components of the dermis and epidermal regeneration. Regarding the cellular mechanism of the wound-healing process, tremendous progress has been made in recent years in identifying the critical events responsible for wound healing. This step is essential in establishing the greater tensile strength of the skin. Lastly, the remodeling step involves the remodeling and realignment of the collagen tissue. In addition, at the epidermal layer, keratinocytes are the cells responsible for epithelialization of the stratum corneum at skin layer resulting in the epidermal regeneration and the wound contraction. This process is characterized by the involvement of the cells embedded in the skin layers including specialized fibroblasts, which secrete a collagen framework onto the dermal skin layer in order to facilitate dermal regeneration. On approximately the 4th day after wounding, the proliferation phase begins. The second step involves the inflammation utilized by neutrophils and macrophages in response to tissue injury via cytokine release and phagocytosis. Hemostasis is the first immediate step that occurs at the wound site and requires platelets to repair damaged blood vessels through the process of blood clotting. In brief, there are four stages of the wound-healing process. The wound-healing process is a complex sequence of cellular and molecular processes that consist of inflammation, new tissue formation, and tissue remodeling. Overall, our results indicate that the wound-healing activities of AAP can be applied in an AAP-based product for wound management. Specifically, the AAP significantly accelerated the wound closure in a mice skin wound-healing model on day 9 (2.5%AAP, p = 0.031 vs. AAP significantly promoted both fibroblast and keratinocyte proliferation, migration, and invasion, along with augmentation of the wound-healing process by increasing collagen synthesis and decreasing E-cadherin expression (All p < 0.05). AAP displayed antioxidant activity in vitro and was able to abort UVB-induced intracellular ROS production in human fibroblasts in cellulo. The main sugar composition of AAP includes mannose, galactose, and glucose. AAP contained high amounts of polysaccharides (349.83 ± 5.00 mg/g extract) with a molecular weight of 158 kDa. In this study, we have reported on the mechanisms that promote the wound-healing effects of a water-soluble polysaccharide-rich extract obtained from A. Auricularia auricula-judae, a nutrient-rich mushroom used in traditional medicine, is a macrofungi that exhibits various biological properties.
0 Comments
Leave a Reply. |